CJC-1295: GHRH Analogue — Complete Scientific Analysis
Educational Content Only
The information on this page is based on scientific publications and is for educational purposes only. It does not constitute medical prescription, diagnosis, therapeutic guidance, or recommendation for use. Any clinical intervention must be individualized by a qualified healthcare professional.
⚠️ The information on this page is based on scientific publications and is for educational purposes only. It does not constitute medical prescription, diagnosis, therapeutic guidance, or recommendation for use. Any clinical intervention must be individualized by a qualified healthcare professional.
Educational analysis of CJC-1295: differences between DAC and non-DAC versions, mechanism as GHRH analogue, clinical trial data from Teichman et al. (2006) and synergism with GHRP.
Mechanism of Action
CJC-1295 is a synthetic GHRH analogue with an extended half-life via DAC (Drug Affinity Complex) chemical modification. It binds to the GHRH-R receptor on somatotroph cells of the anterior pituitary, stimulating pulsatile GH release in a physiological manner.
GHRH-R Receptor Binding
CJC-1295 binds with high affinity to the GHRH receptor in the anterior pituitary. The DAC modification allows transient covalent binding to serum albumin, extending half-life from minutes (native GHRH) to 7–10 days.
cAMP/PKA Pathway Activation
Binding to Gs-coupled GHRH-R activates adenylate cyclase → cyclic AMP (cAMP) elevation → PKA activation → CREB phosphorylation → GH gene transcription and secretory vesicle exocytosis.
Hepatic IGF-1 and Anabolic Effects
Increased GH stimulates hepatic IGF-1 synthesis, mediating anabolic effects: increased muscle protein synthesis, fatty acid mobilization (lipolysis), nitrogen retention, and bone metabolism.
- •GHRH-R agonist with 7–10 day half-life (DAC version)
- •Maintains physiological pulsatile GH secretion pattern
- •Frequently combined with secretagogues like Ipamorelin for synergistic effect
Applications Described in Literature
GH Deficiency and Body Composition
Moderate evidenceStudies demonstrate that CJC-1295 significantly increases GH and IGF-1 levels. In a phase II clinical trial, weekly doses produced IGF-1 elevations of 28–43% sustained for up to 28 days, with improvements in body composition. Literature describes protocols of 1–2 mg weekly in adults with GH deficiency.
Muscle Recovery and Performance
Preliminary evidenceVia IGF-1 elevation, pre-clinical literature and case reports describe improvements in muscle recovery, protein synthesis, and visceral fat reduction. Described protocols combine CJC-1295 with Ipamorelin to amplify GH peak.
Sleep Quality and Systemic Recovery
Preliminary evidenceGH has predominant secretion during slow-wave sleep (N3). Studies with GHRH analogues demonstrate improvements in sleep architecture, with increased deep sleep. Observational literature describes benefits in systemic recovery and subjective well-being.
Relevant Studies
2 curated studies · 2005–2006
Peer-reviewed evidence with PMID verifiable on PubMed
Growth hormone-releasing factor (GRF) analogs: CJC-1295, a long-acting GRF analogue
Jetté L, Léger R, et al. · Journal of Clinical Endocrinology & Metabolism
First human study of CJC-1295 (DAC-GRF): dose-dependent elevation of GH and IGF-1 for 7–14 days after single SC dose. Favorable tolerability in healthy adults.
Stimulation of GH secretion by CJC-1295, a long-acting GHRH analogue
Teichman SL, Neale A, et al. · Journal of Clinical Endocrinology & Metabolism
Phase II trial showed CJC-1295 2 mg/week increased IGF-1 by 28–43% for up to 28 days. No suppression of the hypothalamic-pituitary axis after cessation.
Latest literature review: 2026-04 · PubMed
FAQ
CJC-1295 with or without DAC — what is the difference?
CJC-1295 without DAC (also called Mod-GRF 1-29) has a half-life of ~30 minutes, producing physiological GH pulses. The DAC version (Drug Affinity Complex) binds to serum albumin, extending half-life to 6-8 days with a more continuous GH profile.
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